Endocrine Abstracts

Aim: To minimize the duration of vitamin-D insufficiency, current treatment regimes are initiated with an oral bolus dose of cholecalciferol. We have previously developed an algorithm (# Dekristol caps/Vigantol ml =(80 nmol/l – initial [s-25-OH-d-vit])/7 nmol/l) for determining the dosage of this bolus, aimed at reaching a serum 25-OH vitamin-D of 80 nmol/l. Our main aim was to investigate the accuracy of this algorithm.Materials: A retrospective st...

Patients with growth hormone deficiency (GHD) have increased risk of bone fractures. Despite a well-known decrease in bone mineral density (BMD) and content (BMC) in these patients, these changes in bone mineralization cannot explain the increase in fracture rate alone. The purpose of this study was to evaluate collagen morphology in cortical bone from GHD rats in order to provide a further explanation for the increased fracture rate seen in GHD patients.<p class="abstext...